Digoxin is one of the oldest drugs used in modern medicine. Over 200
years ago a country doctor discovered that an extract of foxglove leaves
helped patients with heart failure. The modern drug is produced chemically;
it has the same effect as the older crude extract of foxgloves but it can be
used with much greater precision.
During exercise the heart pumps more blood around the body as a
result of natural mechanisms including the hormone adrenaline, which
makes the heart muscle beat more strongly. Digoxin has a similar effect; it
increases the strength of the heart’s contraction. It also has a quite separate
action in keeping the rate and rhythm of the heart-beat regular.
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